-Abstract-
Antifungal activities of the to antifungal substances, HWY-87 and HWY-89 extracted
from Corydalis turtschaninovii were examined using several yeast types and filamentous
fungi including C. albicans and A. nidulans. The antifungal activities of the two
substances were also compared with two comercial antifungal drugs, KCZ and MCZ and
the result reads as follows.
1. The activity spectrum of the antifungal substances on C. albicons showed the
concentration of 5ug in HWY-89, 25ug in HWY-87, 5ug in MCZ, and 50ug in KCZ and
the inhibitory effect on cell grwoth showed statistically significant difference. (p＜0.001)
2. Yeast type fungi, C. albicans, Cr. neoformans and S. sereviziae showed the inhibitory
effect in the cell growth at the concentration of 25ug in HWY-89.
3. In filamentous fungi, Al. mali, the cell growth inhibitory zone was significantly
formed at the concentration of 50ug in MCZ. (p＜0.01)
4. In the index of the growth of C. albicans, the fungicidal effect showed at the
concentration of 25ug in HWY-89 in four hours.
5. In the experiment of the survival of A. nidulans, fungicidal effect showed at the
concentration of 50ug in HWY-89 and MCZ in eight hours.
As the result, HWY-89 of antifungal substances extracted from Corydalis turtschaninovii
showed the strong antifungal effect and showed higher antifungal effect in yeast type
fungi than filamentous fungi.
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